What are clinical trials and how do they work?

A clinical trial is a research study designed to learn how our bodies respond to medicines or other treatments. Clinical trials:

  • Test new ways to help prevent, find, diagnose, or treat diseases
  • Help find out if new investigational treatments, or new uses for existing treatments, are safe and work well

Clinical trials are sometimes called clinical studies and clinical research.

Clinical trials happen in phases

Before health authority approval, any treatment (vaccine, medicine, medical device, or procedure) must go through 3 phases of clinical trials. Sometimes phase 4 trials are conducted after approval. Each phase tests the treatment’s safety, how well it works, amount (dose), and side effects. Participation in clinical trials is voluntary.

GettyImages-1196955874

The importance of diverse participants

Age, race, gender, ethnicity, and many other factors play into how a person will react to an investigational medication treatment. To find out if a treatment is safe and works well for all people, researchers must have diverse participants in clinical trials. To read more about MSD’s commitment to diversity in clinical trials, visit our Diversity section.

Visit our Diversity page

Clinical trial participation

Taking part in a clinical trial is a process. We’ve outlined the steps you can expect before, during, and after being in a clinical trial.

Visit our Participation process page

GettyImages-865900230
GettyImages-605381119

What to consider before joining

Before you decide if you’ll join a clinical trial, learn as much as possible about it. You should feel comfortable asking the researchers all your questions about the trial, the care you can expect, and if there are costs. Explore our list of questions to ask the research team.

Visit our What to consider page

Still have questions?

Our FAQ section has answers to commonly asked questions and a glossary of words to know.

Frequently asked questions

Glossary

A clinical doctor giving some test results to a couple of elderly patients in hospital.
This site is registered on wpml.org as a development site. Switch to a production site key to remove this banner.